SimCP

A simulation platform to predict gait performance following orthopedic intervention in children with cerebral palsy

A simulation platform to predict gait performance following orthopedic intervention in children with cerebral palsy

SimCP.be

The motivations behind this project are (1) the observation that it is very difficult to predict the functional outcome of a clinical treatment in children with cerebral palsy (CP), which often leads to follow-up treatments with an important socio-economic impact; and (2) the recent scientific progress in the domain of subject-specific neuro-musculoskeletal modeling which enables the development of computer simulations to predict the functional outcome for individual patients. Therefore, this project aims to create SimCP, a simulation platform that will enable the clinicians to compare the effect of different treatments and to determine which treatment has the highest potential of improving gait performance before the intervention.

 

The scientific objectives are the following.

1. To subject-specifically model the musculoskeletal system of children with CP. To this aim, a previously proposed workflow for MRI based subject-specific modelling of the musculoskeletal geometry that has been applied to model children with CP, will be applied. In addition, a previously proposed workflow to estimate the force generating capacity of the muscles based on functional strength measurements in healthy subjects will be tailored towards application in children with CP, in which it is harder to measure maximal strength due to the impaired motor control.

 

2. To subject-specifically model motor control of children with CP. Spasticity will be assessed and modelled based on the results of a previous IWT-TBM project (IPSA). In addition, the lack of selective motor control will be modelled through the determination of muscle synergies from EMG measured during functional activities. The models describing spasticity and selective muscle control will be added to the musculoskeletal model creating a subject-specific neuro-musculoskeletal model.

 

3. To calculate the change in the capability gap pre- and post-treatment using a workflow previously proposed by the consortium. The capability gap is the difference between the capability of the patient and the capability needed to achieve normal gait. For the calculation of the post-treatment capability gap, the effect of a treatment will be modelled.

 

Data and code will be made available through https://SimTK.org/projects/simcp.


Recording of the SimCP Webinar, part of the NCSRR Webinar Series at Stanford

 


SimCP Events

 


Contact Person:

Ilse Jonkers - Friedl De Groote

Hans Kainz - Mariska Wesseling

Sam Van Rossom - Lorenzo Pitto

Antoine Falisse - Hoa Hoang

 

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     Ilse Jonkers

  • PI

 

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     Friedl De Groote

  • PI

 

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     Hans Kainz

  • Post doctoral researcher

 

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     Mariska Wesseling

  • Post doctoral researcher

 

  > Contact

     Sam Van Rossom

  • Post doctoral researcher

 

  > Contact

     Hoa Hoang

  • Post doctoral researcher

 

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     Lorenzo Pitto

  • PhD Student

 

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     Antoine Falisse

  • PhD student