Research
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Publications from the division
On-line PhD theses
Research projects
Ongoing research (in close collaboration with the Division of Radiopharmacy)
Fundamental
| Quantitative and translational molecular imaging of the cannabinoid-type 1 receptor and its dopaminergic interactions in Parkinson's and Huntington's disease FWO/G.0548.06 2006-2009 |
| Signal transduction inhibitors as a treatment of gastro-intestinal stromal tumours: Confirmation of the concept in a nude mouse model, testing new compounds and evaluation of response by micro-PET scan. FWO (3M050037) 2006-2009 |
| Endophenotypes in depression OT/06/... 2006-2009 |
| Mechanisms of regional dysfunction and remodeling in ischemic cardiomyopathy GOA 2006-2008 |
| Ga-68 DOTATOC, evaluation of a new PET tracer in neuro-endocrine tumours Klinisch Onderzoeksfonds 2006 |
| Validation of new Integrated International Workshop Criteria in therapy evaluation of lymphoma Cycle for Life 2006 |
| Quantitative, in vivo molecular imaging of the human cerebral CB1-receptor in epilepsy, eating disorders and movement disorders OT/05/58 2005-2009 |
| Impact of abnormal mechanical loading by adjacent and remote myocardium on the contractile dysfunction of chronically ischemic, viable myocardium FWO (3M060753) 2005-2009 |
| Central mechanisms underlying visceral hypersensitivity in man FWO (3M040039) 2005-2008 |
| In vivo PET imaging of the cannabinoid-type 1 receptor and its GABA-A interactions in epilepsy. FWO (3M050225) 2005-2007 |
| Longitudinal microPET study of epileptogenesis and the epileptic network in two animal models of epilepsy: identification of functional cerebral targets for electrical stimulation as treatment of epilepsy. FWO G.0227.05 2005-2007 |
| Stamcel Instituut Leuven. Excellentiefinanciering KUL 2005- |
| Structure and function of the cerebral cortex in human and non-human primates (from single cells to deficits in patients) - Leuven Cerebral Cortex Centre (LCCC). Excellentiefinanciering KUL - EF/05/014 2005- |
| In vivo morphological, functional and molecular imaging of small animal models. Excellentiefinanciering KUL 2005- |
| Diagnostic Molecular Imaging (DIMI) - Network of Excellence European Community (click here for latest version of project PDF - intranet access only) EU FP6 - LSH-2003-1.2.2-2 2004-2009 |
| In-vivo measurement of chemotherapy-induced changes to the glucose and DNA metabolism in tumours : a (micro) PET study. FWO G.0177.04 2004-2008 |
| Non-invasive evaluation and improved selection of patients for epilepsy-churgery with new imaging-and reconstruction techniques (MRI, PET en SPECT) IDO/03/010 2004-2007 |
| Molecular imaging for biologically optimised cancer therapy Biocare LSH 2002-2.2.0-5 2003-2005 |
| In vivo molecular imaging of the central nervous system. IDO/02/012 (3M020465) 2003-2007 |
| The use of biologic markers (glucose metabolism, hypoxia, proliferation) assessed by positron emission tomography to predict and assess the response to treatment in pharyngeal and esophageal cancer FWO G.0175.03 (3M020042) 2003-2006 |
| Development and non-invasive monitoring of new animal models based on local, somatic transgenesis for a better diagnosis and therapy of neurodegenerative disease SBO - ANIMONE 2003-2007 |
| Regularization techniques in emission tomography. FWO G.0174.03 (3M020061) 2003-2006 |
| Mechanisms of the pulmonary and cardiovascular effects of particulate air pollution. OT/02/45 2002-2006 |
Clinical
Evaluating diagnostic challenges in the management of neuroendocrine tumors and implementing the therapeutic approach of peptide receptor radionuclide therapy |
| Dedection of infectious foci in patients with endocarditis 2006-2007 |
| Prospective evaluation of small molecule EGFR-1 tyrosine kinase inhibition as first-line treatment in patients with advanced NSCL cancer harbouring a mutant EGFR gene 2006- |
| Differential diagnosis between infection and lymphoma 2006- |
| Brain receptor study in healthy volunteers, anorexia/boulemia patients, epilepsy and movement disorders 2005-2007 |
| Brain stimulation - depression 2005-2007 |
| Diagnosis of Kahler with MIBI-SPECT and PET-CT 2005-2006 |
| Stomach sensitivity in normosensitive FD patients. 2005-2006 |
| Phase III in colorectal tumour patients with liver metastases. 2005- |
| Radiotherapy in patients with head/neck tumors 2005- |
| Brain receptor study in Alzheimer's disease 2005 |
| Cerebral uptake of 6-OH-BTA1 in Alzheimer's disease 2004- |
| Influence of gastric distribution on gastroesophageal reflux 2004- |
| Treatment of patients with gastro-intestinal stromal tumors (GIST) 2003- |
| Stam cell transfer in patients with acute myocard infarct 2003- |
| Therapy treatment in patients with esophageal cancer 2003-2007 |
| Effectiveness of hyperfractionated radiotherapy in patients with head/neck cancer and the role of PET. 2003-2006 |
| Assessment of cardiac involvement and its prognostic implications in sarcoidosis, using non-invasive electrocardiographic and imaging techniques 2003- |
| NeoTect for Assessing Response to (h)Ormonal Treatment in Advanced Breast cancer patients (NAROTA-B study) 2002- |
Pharmaceutical
Because of intellectual property reasons, no public details can be given concerning the content of these studies at this time.
| Johnson & Johnson Regional brain glucose metabolism 2006 |
| Merck & Co.,Inc Advanced breast, colon and lung cancer 2004- |
| Merck & Co.,Inc Brain receptor 2004- |
| AMGEN Gastro-intestinal stromal tumors 2004- |
| Bristol-Myers-Squibb Breast cancer 2004- |
| Pfizer Inc. Advanced/metastatic solid tumors 2004- |
| Boeringher Ingelheim Acute Myocardial Infarction 2004- |
| AstraZeneca Prostate cancer 2004- |
| GE Healthcare Heart Failure 2004- |
| Novartis Adult patients with advanced cancer 2003- |
| Novartis Phase I-II : Gastro-intestinal stromal tumors 2002- |
| Genzyme MAGIC Ischemic Heart Disease 2002- |
| Schering Non-Hodgkin’s lymphoma 2001- |
Finished research projects (1998-2002)
Fundamental
| Purchase of a new cyclotron and a Good Manufacturing Practice (GMP) installation. Project 'Acquisition of Large Infrastructures', launched by Minister Dirk Van Mechelen, Flemish minister for Sciences and Technological Innovation. 2003-2005 |
| Molecular imaging of tumors, ischemic and degenerative brain pathology and transgene expression in animal models by microPET : pathophysiological typing and therapy evaluation. FWO G.0289.03 (3M020041) 2003 |
| The virtual radiopharmacy - a mindful learning environment. VIRRAD (3M020433) 2002-2005 |
| In vivo measurement of gene expression with Positron Emission Tomography : optimalisation of the methodology in a possible prostate model and application on transgene animal models of neurodegenerative disease. FWO (3M020158) 2002-2004 |
| Evaluation of the predicitve value of sequential Tc99m depreotide scintigraphy for response and origin of resistance on endocrine therapy on patients with metastasized breast cancer. FWO Klinisch Onderzoeksfonds 2002-2003 |
| Exercise tolerance and effects of physical training in patients with cardiovascular disease: genetic determinants and explanatory mechanisms. FWO G.0124.02 (3M010125) 2001-2005 |
Synthesis and evaluation of C-11 and F-18 glucose derivates for in vivo visualisation of SLGT transporters with PET. |
| Statistical reconstruction techniques for image formation in 'single photon' emission tomography. OT/00/32 (3M000018) 2000-2004 |
| Development and evaluation of radiolabelled tracer agents with affinity for amyloid for study and in vivo visualisation of amyloid deposits in patients with Alzheimer's disease. OT/00/39 (3M000335) 2000-2004 |
| Non-invasive evaluation and improved selection of patients for epilepsy surgery with new imaging and image analysis techniques (MRI, PET and SPECT). IDO 99/005 (3M000156) 2000-2004 |
| Use of hypericin in the photodynamic therapy of superficial bladder transitional cell carcinoma. GOA/2002/12 (3M000423) 2000-2004 |
| Development and evaluation of radiolabelled tracerproducts for diagnosis of Alzheimer's disease and peripheral amyloidosis. FWO (3M010193) 2000-2004 |
| Human neurobiology of brain-gut interactions in gastric (hyper)sensitivity. FWO Research Project 2000-2003 |
| The development, optimisation, validation and implementation of an automated system for the acquisition, processing, analysis and quantification of functional brain single photon emission tomography Onderzoeksprogramma Bilaterale Wetenschappelijke en Technologische Samenwerking BIL99/41(3M020041) 1999-2002 |
| Brain mechanism involved in orienting: attention and motor responses. Medical Foundation Queen Elisabeth 1999-2001 |
| Experimental study hibernating myocardium with PET: correlation with functional, biochemical and ultrastructural parameters. FWO G.0347.98 1998-2002 |
| Neurophysiological mechanisms underlying human visual perception, attention,memory and knowledge : PET investigations FWO G.0358.98 1998-2002 |
Development and evaluation of iterative algorithms for reconstruction of transmission measurement, in order to improve the signal-to-noise ratio in emission and transmission tomography |
| Experimental and clinical study of the value of PET with 18F FDG and 11C Methionine for the evaluation of early respons to treatment of lymphomas. FWO Krediet aan Navorsers G.0298.97N 1998-2001 |
| Development and evaluation of technetium-99m peptides with high affinity for tumour receptors for the study of neuro-endocrine tumours and small cell lung carcinoma. FWO Research Fellowship (3M970118) 1997-2004 |
| Study of the pathofysiological mechanisms and diagnosis of hibernating myocardium using PET. Correlation with functional, histopathological and biochemical parameters. OT 96/25 1996-2000 |
Clinical
| Gastroesophageal reflux and gastric emptying : Simultaneous measurement of acid and non-acid gastro-esophageal reflux during gastric emptying of refluxogenic meal. 2002-2003 |
National Institute of Health |
| Verbeeten Instituut Tilburg Positron emission tomography in the region Tilburg: an observatory, prospective management study. Part 1: lung carcinoma 2002-2003 |
| EORTC After mapping of the axilla: radiotherapy or surgery? 2000-2003 |
| G.0126.00 A clinical and experimental evaluation of non-invasive diagnostic techniques in interstitial lung disease. 2000-2003 |
| Treatment of temporal arteritis and polymyalgia rheumatica. 2000-2004 |
Pharmaceutical
Because of intellectual property reasons, no public details can be given concerning the content of these studies at this time.
| AstraZeneca New Drug Therapy Evaluation in Advanced Non-Small Cell Lung Cancer Patients 2004 |
| Pfizer Metastatic breast cancer 2003- |
| Theseus Apoptosis in Small Cell Lung Cancer 2003-2004 |
| Theseus Apoptosis in Non-Small Cell Lung Cancer 2003-2004 |
| Merck & Co.,Inc Brain GABA-A receptor study. 2003 |
| KS Biomedix Unresectable pancreatic adenocarcinoma 2002-2004 |
| Amersham Health Pulmonary embolism 2002-2004 |
| Theseus Apoptosis - healthy volunteer study. 2002 |
| Wyeth Ayerst Léderlé Myocardial infarction. 2000-2002 |
| Wyeth Ayerst Léderlé Myocardial infarction. 2000-2002 |
| Merck & Co.,Inc Brain GABA-A receptor study. 2000-2001 |
| Novartis PET in sarcoma patients. 2000-2002 |
| Novartis Advanced cancer patients. 1999-2002 |
| Amersham Prostate cancer - radionuclide therapy. 1997-2003 |
Ongoing PhD Theses
Main Domain: Nuclear Medicine
| Esther Wolfs Optimization of radiolabeling strategies for stem cell imaging with positron emission tomography and single photon emission computed tomography. |
| Olivier Gheysens Molecular imaging of stem cell transplantation and apoptosis in the heart of mice and rats. |
| Karolien Goffin In vivo (micro)PET beeldvorming van de type 1 cannabinoid receptor bij epilepsie |
| Natalie Nelissen In vivo humane studies van de pathogenese bij de ziekte van Alzheimer |
| Caroline Vandeputte Stem cell labeling, tracking and functional evaluation with microPET technology. |
| Nathalie Gérard Translational in vivo molecular imaging of the type 1 cannabinoid receptor in eating disorders |
| Marijke De Saint-Hubert Screening of new anti-cancer drugs in an animal tumour-model |
| Kimy Emonds From Cellular Pathofysiology to Molecular Imaging of Prostate Carcinoma |
Jenny Ceccarini |
Carolien Vaerenberg |
Main Domain: Medical Imaging
| Lin Zhou Prediction of image quality in emission tomography |
Ameya Atre |
Main Domain: Radiopharmacy
| Kim Serdons Preparation and evaluation of Fluor-18 marked 2-fenylbenzothiazols as tracer products in the diagnosis of Alzheimer's disease |
| Nele Evens Development and biological evaluation of PET radioligands for visualization of the cannabinoid type 2 receptor |
| Vamsidhar Akurathi Development of radiopharmaceuticals for the in vivo visualisation of carbon anhydrase IX expression as surrogate markers of tumor hypoxia |
| Kristof Prinsen Development and biological evaluation of radioactive tracer products for rapid and early detection of necrosis |
| Daisy van Veghel Development and evaluation of carbon-11 and fluorine-18 labeled tracers for in vivo visualization of the TRPV1 receptor by positron emission tomography (PET) |
Networking
Intrauniversity collaborations
- Division of Cardiology, UZ Leuven
- Experimental Neurology Section, K.U.Leuven
- Division for Experimental Neurosurgery and Neuro-anatomy, K.U.Leuven
- Laboratory of Radiopharmaceutical Chemistry, K.U.Leuven
- Laboratory for Pharmaceutical Biology and Phytopharmacology, K.U.Leuven
- Division for Oncology and Experimental Radiotherapy, K.U.Leuven
- Centre for Experimental Surgery and Anaesthesiology, K.U.Leuven
- Division for Gastro-Enterology, K.U.Leuven
- Department of Molecular and Cardiovascular Research, K.U.Leuven
- Laboratory for Molecular Virology and Gene Therapy, K.U.Leuven
- Division for Pneumology, K.U.Leuven
- Medical Image Computing, K.U.Leuven
- Centre for Clinical Pharmacology, UZ Leuven
Interuniversity collaborations
- University of Kortrijk - KULAK (Belgium) (Dutch)
- University of Brussels - VUB (Belgium)
- University of Louvain-la-Neuve - UCL (Belgium)
- University of Ghent - UG (Belgium)
- University of Antwerp - UIA (Belgium)
- University Hospital Maastricht, The Netherlands (Dutch)
- University of Cologne
- University of Maastricht (Dutch)
Industry collaborations
